Understanding the Medical Applications of THC, CBD, and CBN

Medical Applications and Use Cases

Pain Relief: Effective for chronic pain relief but may cause euphoria and sedation. Starting dose: 2.5-5mg THC.
Anxiety Reduction: May reduce anxiety at low doses but can exacerbate it at higher doses.
Anti-Inflammation: Shows promise in reducing inflammation but is less studied than CBD.
Sleep Aid: Often used for insomnia but may lead to grogginess upon waking.

Pain Relief: Effective for neuropathic pain, less psychoactive impact. Starting dose: 5-10mg CBD.
Anxiety Reduction: Widely used for anxiety and PTSD.
Anti-Inflammation: Proven efficacy for treating inflammation.
Epilepsy Control: Proven effective for certain forms of epilepsy such as Dravet syndrome.

Pain Relief: Less potent than THC and CBD but has potential. Starting dose: 2.5-5mg CBN.
Sleep Aid: Known for its sedative effects.
Anti-Inflammation: Some evidence supporting anti-inflammatory potential.
Antibacterial: Exhibits antibacterial properties, especially against MRSA.

Aspect	Questions to Ask	THC	CBD	CBN
Pain Relief	What type of pain do I have?	Effective for chronic pain	Effective for neuropathic pain	Less potent but promising
Anxiety Reduction	Am I prone to THC-induced anxiety?	Dose-dependent effects	Widely used for anxiety	Not well-studied
Anti-Inflammation	Do I have a gastrointestinal disorder?	Promising but less studied	Proven efficacy	Some evidence
Epilepsy Control	Do I have a form of drug-resistant epilepsy?	Limited studies	Effective for Dravet syndrome	Not well-studied
Sleep Aid	Do I have trouble falling asleep or staying asleep	Effective but may cause grogginess	Limited evidence	Known for sedative effects
Antibacterial	Am I looking for antibacterial properties?	Limited evidence	Limited evidence	Effective against MRSA

Russo, E. B. (2011). Taming THC: potential cannabis synergy and phytocannabinoid‐terpenoid entourage effects. British Journal of Pharmacology, 163(7), 1344-1364.
MacCallum, C. A., & Russo, E. B. (2018). Practical considerations in medical cannabis administration and dosing. European Journal of Internal Medicine, 49, 12-19.
Whiting, P. F., Wolff, R. F., Deshpande, S., Di Nisio, M., Duffy, S., Hernandez, A. V., … & Schmidlkofer, S. (2015). Cannabinoids for medical use: A systematic review and meta-analysis. JAMA, 313(24), 2456-2473.
Mechoulam, R., & Hanuš, L. (2002). Cannabidiol: an overview of some chemical and pharmacological aspects. Part I: chemical aspects. Chemistry and physics of lipids, 121(1-2), 35-43.
Appendino, G., Gibbons, S., Giana, A., Pagani, A., Grassi, G., Stavri, M., … & Rahman, M. M. (2008). Antibacterial cannabinoids from Cannabis sativa: a structure− activity study. Journal of Natural Products, 71(8), 1427-1430.

For specialized care for these conditions, consult Dr. Benjamin Caplan at CED Clinic.

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