D6: Influence of Age, Sex, and Body Composition on Metabolism and Effects of Edibles.png

Influence of Age, Sex, and Body Composition on Metabolism and Effects of Edibles


Cannabis contains a range of compounds called cannabinoids, with THC and CBD being the most researched. How our bodies react to edible cannabis products can vary due to several factors including age, sex, and body composition. This article delves into these differentiating aspects.

Age-Related Differences in Cannabis Metabolism

Younger people generally metabolize THC more quickly than older adults due to a higher metabolic rate. This faster metabolism often leads to shorter-lasting effects. However, it’s important to note that younger individuals, especially adolescents, are more susceptible to potential negative impacts of THC on their developing brains.

Sex-Based Differences in Cannabis Response

Men and women don’t react to cannabis in the same way. Women are often more sensitive to THC effects, partly due to estrogen levels affecting the endocannabinoid system. This means women might need smaller doses for similar effects compared to men. Hormonal changes during the menstrual cycle also play a role in how women respond to cannabinoids.

The Role of Body Composition

Your body’s make-up—like how much muscle or fat you have—can also affect how you react to cannabis. THC is more soluble in fat, which means that people with higher body fat percentages could experience longer-lasting effects. In contrast, those with more muscle mass and a higher metabolic rate might process THC more quickly, resulting in shorter-lasting effects.

Metabolic Pathways of Edibles

Eating a cannabis product is different from smoking it. When you ingest cannabis, your liver turns THC into a compound called 11-hydroxy-THC, which is even more psychoactive than THC. This transformation takes time—usually 1-3 hours—which means it might take a while for you to feel the effects as the compounds first need to be digested and absorbed.

Medical Implications of Cannabis

While research is ongoing, certain medical conditions have shown positive responses to cannabis-based treatments. CBD is being explored for its potential in treating chronic pain, epilepsy, and multiple sclerosis. THC is often used to stimulate appetite, relieve pain, and reduce nausea in chemotherapy patients.


Recognizing how age, sex, and body composition influence the metabolism and effects of edible cannabis products is essential for both maximizing therapeutic benefits and minimizing risks. Always consult healthcare professionals for advice tailored to your individual needs. The existing scientific evidence holds promise for future cannabis-based therapies for a variety of medical conditions.

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