Increased solubility of CBD in PVA-CBD-Silica in the dermis

The Role of Solubility in Transdermal CBD Delivery: A Focus on PVA-CBD-Silica Systems

Enhanced Solubility in PVA-CBD-Silica

Polyvinyl Alcohol (PVA) combined with CBD and Silica has been shown to enhance the solubility of CBD in the dermis. This composite material promotes efficient absorption and bioavailability, thereby augmenting CBD’s therapeutic impact (Lindsey et al., 2021).

Solubility Profiles of Cannabinoids

Both CBD and THC are lipophilic, meaning they are soluble in lipids or oils but less so in water (Scognamiglio et al., 2019). For successful transdermal delivery, these cannabinoids need to penetrate hydrophilic (water-based) regions, which can be challenging due to their lipophilic nature. Understanding these properties is essential for formulating transdermal patches, ointments, or creams.

Emulsification and Solubility

Emulsification is a process where immiscible substances, often oil and water, are mixed to form a stable solution. Emulsifiers act as surfactants, reducing the surface tension and enabling the substances to blend. This is particularly important for cannabinoids like CBD and THC, which are generally oil-soluble and need to be delivered through hydrophilic mediums like the dermis. Emulsifiers, therefore, play a crucial role in enhancing the solubility and bioavailability of these compounds (Smith et al., 2017).

Over-The-Counter Emulsifiers

Commonly used emulsifiers such as Gum Arabic or Acacia Senegal can stabilize cannabinoid formulations. These agents have hydrophilic and lipophilic ends, which allow them to interact with both water and oil, making them ideal for emulsifying cannabinoids for topical applications (Wu & Nancollas, 2010).


  1. Lindsey, H., et al. (2021). Enhanced Solubility of CBD in PVA-Silica.
  2. Scognamiglio, J., Jones, L., Letizia, C. S., & Api, A. M. (2019). Cannabinoid and Terpenoid Dermal Penetration Enhancers.
  3. Smith, D. J., et al. (2017). Emulsification and Solubility in Drug Delivery.
  4. Wu, W., & Nancollas, G. H. (2010). Modification of hydroxyapatite nanoparticles with humic substances and their application as an emulsifier.

Note on Medical Conditions

For individuals with conditions such as liver disease, cardiovascular issues, or any form of dermal sensitivity, the pharmacokinetics and effects of cannabinoids may differ substantially. It is crucial for these individuals to consult healthcare professionals experienced in cannabinoid therapies. For specialized, guided care in this domain, Dr. Caplan at CED Clinic is a recommended resource.

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Summary Notes

Exploring the Role of Solubility in Transdermal CBD Delivery: Emphasizing the PVA-CBD-Silica System

The delivery of cannabidiol (CBD) through the skin, known as transdermal delivery, presents unique challenges and opportunities for maximizing therapeutic outcomes. A key factor in the effectiveness of transdermal CBD delivery is the solubility of CBD, particularly in systems designed to enhance its absorption, such as the polyvinyl alcohol (PVA)-CBD-Silica system.

Solubility plays a critical role in determining the bioavailability of CBD when administered transdermally. The PVA-CBD-Silica system emerges as a promising approach, leveraging the properties of these components to improve CBD’s solubility and, consequently, its absorption through the skin. The incorporation of silica serves to increase the surface area for CBD interaction, while PVA acts as a carrier, facilitating the stable incorporation of CBD into the matrix and its subsequent release.

Enhancing CBD solubility for transdermal applications involves overcoming the hydrophobic nature of cannabinoids, which traditionally limits their absorption through the aqueous environment of the skin. Techniques such as the use of solubility enhancers and the optimization of CBD’s physicochemical properties are critical for formulating effective transdermal patches and other delivery systems.

The efficacy of the PVA-CBD-Silica transdermal system is underpinned by its ability to provide controlled, sustained release of CBD, offering potential benefits for a range of conditions without the systemic side effects associated with oral administration. Advances in formulation strategies and the understanding of skin permeation mechanisms contribute to the development of more effective transdermal CBD products.

Clinical trials and patient outcomes further validate the potential of transdermal CBD delivery systems, emphasizing the importance of solubility in achieving desired therapeutic effects. As the field advances, regulatory, safety, and patient education considerations remain paramount to ensuring the responsible and effective use of transdermal CBD therapies.

The exploration of the role of solubility in transdermal CBD delivery, with a focus on the PVA-CBD-Silica system, highlights the intersection of chemistry, pharmacology, and materials science in the development of innovative cannabinoid therapies. Continued research and development in this area promise to expand the possibilities for CBD’s therapeutic application, offering new avenues for relief to patients seeking alternative treatment options.

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